Status:
COMPLETED
Pharmacokinetics/Pharmacodynamics (PK/PD) of Caspofungin in Intensive Care Unit (ICU) Patients. An Open Observational Study for Antifungal Treatment's Optimization
Lead Sponsor:
Careggi Hospital
Conditions:
Critical Illness
Infection
Eligibility:
All Genders
Brief Summary
PK of Caspofungin in ICU septic patients might be changed as compared to healthy volunteers due to sepsis-related pathophysiology. Sub-optimal plasma and tissue concentrations might be achieved in th...
Detailed Description
Open non randomized, non controlled single center study on the pharmacokinetics of caspofungin in 20 consecutive ICU patients with severe sepsis or septic shock, requiring caspofungin therapy and PK-P...
Eligibility Criteria
Inclusion
- Adult ICU patients (\>18 yrs)
- Severe sepsis or septic shock
- Caspofungin therapy based on clinical judgement (empiric therapy) or microbiological result (targeted therapy).
Exclusion
- Concomitant ciclosporin or rifampicin therapy.
- Pregnancy
- Continuous renal replacement therapy
- Severe Liver failure (Child Pugh score \> 6)
Key Trial Info
Start Date :
January 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03798600
Start Date
January 1 2016
End Date
December 31 2018
Last Update
January 17 2019
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