Status:
UNKNOWN
Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study
Lead Sponsor:
King's College London
Conditions:
Cardiovascular Diseases
Ischemic Cardiomyopathy
Eligibility:
All Genders
18+ years
Brief Summary
The study will investigate whether a new high resolution heart Magnetic Resonance Imaging scan, combining assessment of ischemia and viability by perfusion and Late Gadolinium Enhancement -Cardiac Mag...
Detailed Description
Coronary artery disease, where the heart's blood supply is restricted by narrowings or blockages, is the commonest cause of heart failure. This condition is called ischaemic cardiomyopathy. In some pa...
Eligibility Criteria
Inclusion
- Known coronary artery disease referred for isolated surgical revascularisation;
- Wall motion abnormalities at rest in at least two adjacents segments on standard AHA model supplied by a diseased coronary artery;
- LV EF \<45%.
Exclusion
- Contraindications to CMR, adenosine and low-dose dobutamine;
- GFR \<30 ml/min
- Decompensated heart failure requiring inotropic support, invasive or non-invasive ventilation or Intra-aortic Ballon Pump/left ventricular assist device therapy \< 72 hours prior to enrolment;
- Sustained Ventricular Tachycardia/Ventricular Fibrillation\<72 hours prior to enrolment;
- Implantable Cardioverter Defibrilator;
- Pregnancy;
- Age\<18 years
- Previous established diagnosis of non ischaemic cardiomyopathy;
- Severe concomitant valvular disease;
- Recente acute coronary syndrome(\<4 weeks prior to enrolment).
Key Trial Info
Start Date :
March 3 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2022
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT03798652
Start Date
March 3 2019
End Date
June 30 2022
Last Update
August 19 2019
Active Locations (1)
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1
King's College London
London, United Kingdom, SE1 7EH