Status:
COMPLETED
Study of Exosomes in Monitoring Patients With Sarcoma (EXOSARC)
Lead Sponsor:
Centre Georges Francois Leclerc
Collaborating Sponsors:
INSERM UMR1231 Lipids Nutrition Cancer
Conditions:
Sarcoma
Eligibility:
All Genders
18+ years
Brief Summary
Sarcomas are rare cancers with a high risk of metastatic progression and a major pejorative factor with respect to patient survival. The estimation of the metastatic risk of sarcomas is very complex g...
Detailed Description
The main objective of this pilot study is to quantify exosomes and analyze their protein and RNA content in patients with sarcoma with disease: * localized before and after treatment with surgery, * ...
Eligibility Criteria
Inclusion
- Men and women newly diagnosed with localized, metastatic or locally advanced soft tissue sarcoma
- Previous treatment of the disease with chemotherapy, radiotherapy or surgery is allowed if it has been completed for more than 12 months at the time of inclusion.
- For metastatic or locally advanced (inoperable) sarcoma, patients for whom first-line metastatic chemotherapy is indicated.
- Age ≥18 years
- Affiliation to a social security scheme
- Patients who signed informed consent to participate in the study
Exclusion
- Patients who meet at least one of the following criteria will not be eligible:
- Patient with another synchronous tumor,
- Patient with sarcoma in irradiated territory
- Patient with a history of cancer other than sarcoma in the 5 years preceding the diagnosis of sarcoma
- Patient unable to undergo medical follow-up for geographical, social or psychological reasons,
- Person benefiting from a protection system for adults (including guardianship and trusteeship),
- Serology HIV and / or HBV and / or HCV positive.
- Pregnant or lactating woman.
- Patients unable to understand, read and / or sign informed consent.
Key Trial Info
Start Date :
November 19 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 19 2024
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT03800121
Start Date
November 19 2018
End Date
November 19 2024
Last Update
June 5 2025
Active Locations (3)
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1
CHU de Besançon
Besançon, France, 25000
2
Centre Georges François Leclerc
Dijon, France, 21000
3
CHU de Poitiers
Poitiers, France, 86000