Status:
COMPLETED
Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health
Lead Sponsor:
Laval University
Collaborating Sponsors:
Ministry of Agriculture, Fisheries and Food, Quebec
Ministry of economic development, innovation and export trade, Quebec
Conditions:
Endotoxemia
Metabolic Syndrome
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's pro...
Detailed Description
It is now recognized that overweight individuals have altered microbiota which could lead to intestinal barrier defects and chronic inflammation disorders. Polyphenols such as Proanthocyanidins may mo...
Eligibility Criteria
Inclusion
- overweight (BMI 25-39.9 kg/m2) or waist circumference ≥ 80 cm (women) and ≥94 cm (men)
- fasting insulin over 60 pmol/L or fasting glucose 5.6 - 6.9 mmol/L
- at least one of the following criteria: Tg ≥ 1.7 mmol/L; blood pressure ≥ 130/85 mmHg; HDL \< 0,9 mmol/L; hsCRP 1-10 mg/L
- non-smoking
- eating fruits and vegetables less then 5 portions/day
Exclusion
- chronic disease
- taking drugs or natural health products that could affect glucose or lipid metabolism
- taking anti-inflammatory, antiacids
- taking pre or probiotics
- inflammatory bowel disease
- antibiotics in the past 3 months
- allergy or intolerance to cranberries or agaves
- Major surgery in the past 3 months
Key Trial Info
Start Date :
November 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT03800277
Start Date
November 5 2018
End Date
December 31 2021
Last Update
March 21 2023
Active Locations (1)
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1
Institute of nutrition and functional foods, Laval University
Québec, Quebec, Canada, G1V 0A6