Status:
COMPLETED
Human Beta-2 Adrenergic Stimulation and Muscle Glucose Uptake
Lead Sponsor:
Maastricht University
Conditions:
Healthy
Eligibility:
MALE
18-30 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to investigate the effect of two weeks clenbuterol/placebo supplementation on skeletal muscle glucose disposal in healthy male volunteers.
Eligibility Criteria
Inclusion
- Caucasian;
- Male sex;
- Age: 18-30
- BMI: 18-25 kg/m2;
- Normal physical activity levels;
Exclusion
- Not meeting all inclusion criteria
- Cardiovascular diseases (determined by means of questionnaires, heart rate/blood pressure measurements)
- Respiratory diseases (including asthma, bronchitis and COPD);
- Unstable body weight (weight gain or loss \> 5 kg in the last three months);
- Intention to lose or gain body weight (e.g. with caloric restriction or physical activity)
- Excessive alcohol and/or drug abuse;
- Hypokalaemia;
- Hb \< 8.4 mmol/L;
- Epilepsy;
- Smoking;
- Renal and/or liver insufficiency;
- Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
- Medication use known to hamper subject's safety during the study procedures;
- Subjects who do not want to be informed about unexpected medical findings;
- Subjects who do not want that their treating physician to be informed;
- Inability to participate and/or complete the required measurements;
- Participation in organised or structured physical exercise;
- Any condition, disease or abnormal laboratory test result that, in the opinion of the Investigator, would interfere with the study outcome, affect trial participation or put the subject at undue risk;
- Hyperthyroidism
Key Trial Info
Start Date :
June 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 23 2021
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03800290
Start Date
June 1 2019
End Date
April 23 2021
Last Update
December 1 2022
Active Locations (1)
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1
Maastricht University
Maastricht, Limburg, Netherlands, 6229ER