Status:
COMPLETED
This Trial is a Randomised, Multicentre, Investigator-blind, Vehicle and Comparator-controlled, Parallel-group Trial With the Purpose of Evaluation Efficacy, Safety and Convenience of the MC2-01 Cream
Lead Sponsor:
MC2 Therapeutics
Conditions:
Psoriasis Vulgaris
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This trial is a randomized, investigator-blind, multicentre, vehicle- and comparator-controlled, parallel-group trial with the purpose of evaluating the efficacy, safety and convenience of the MC2-01 ...
Detailed Description
The MC2-01 Cream is designed for optimal patient satisfaction - it quickly absorbs into the skin leaving it nicely moisturized allowing patients to move on in daily routines. In this trial, the MC2-01...
Eligibility Criteria
Inclusion
- Have provided written informed consent
- Generally healthy males or non-pregnant females, of any race or ethnicity, who are at least 18 years of age at the time of screening
- Have a clinical diagnosis of plaque psoriasis (psoriasis vulgaris) of at least 6 months duration that involves the body (trunk and/or limbs) that is amenable to topical treatment with a maximum of 15 g of trial medication per day
- Have a PGA of disease severity of mild or moderate on the body (trunk and/or limbs)
- Have an mPASI score of at least 3
- Have a treatment area involving 2-30% of the body (trunk and/or limbs). For subjects with scalp psoriasis included in the treatment area, the total treatment area on body and scalp must not exceed 30%.
Exclusion
- Current diagnosis of unstable forms of psoriasis
- Other inflammatory skin disease in the treatment area that may confound the evaluation of the psoriasis vulgaris
- Presence of pigmentation, extensive scarring, pigmented lesions or sunburn in the treatment areas
- Planned excessive or prolonged exposure to either natural or artificial sunlight
- History of hypersensitivity to any component of the test product or reference product
- Current or past history of hypercalcemia, vitamin D toxicity, severe renal insufficiency, or severe hepatic disorders
- Systemic treatment with biological therapies
- Use of systemic treatments that suppress the immune system and other systemic chemotherapeutic antineoplastic therapy within 4 weeks prior to Visit 1/Baseline and during the trial
- Use of phototherapy within 4 weeks prior to Visit 1/Baseline and during the trial
- Use of topical treatments except for emollients and non-medicated shampoos, with a possible effect on psoriasis within 2 weeks prior to Visit 1/Baseline
- Presence of infections in the treatment area (bacteria, viruses, parasites or fungi) or skin manifestations of atrophic skin, atrophic striae, skin vein fragility, ichthyosis, acne vulgaris, acne rosacea, rosacea, ulcers and wound in the treatment area
- Known Human Immunodeficiency Virus (HIV) infection
- Have any chronic or acute medical condition that may pose a risk to the safety of the subject, or may interfere with the assessment of safety or efficacy in this trial
- Initiation of, or expected changes to, concomitant medication that may affect psoriasis
Key Trial Info
Start Date :
December 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 2 2019
Estimated Enrollment :
498 Patients enrolled
Trial Details
Trial ID
NCT03802344
Start Date
December 12 2018
End Date
October 2 2019
Last Update
December 16 2020
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Dermatovenerologie a korektivní dermatologie
Prague, Czechia, Těšnov 1163/5 110 00
2
University Medical Center Hamburg
Hamburg, Germany, 20246