Status:
ACTIVE_NOT_RECRUITING
Aerobic Exercise and Cerebrovascular Function
Lead Sponsor:
VA Office of Research and Development
Conditions:
Aging
Eligibility:
All Genders
65-80 years
Phase:
PHASE2
PHASE3
Brief Summary
This proposal will evaluate two brain health measures, cerebrovascular perfusion and cerebrovascular reactivity (CVR), before and after a proven, interval-based, aerobic exercise intervention in older...
Detailed Description
To address the growing healthcare challenges of an aging Veteran population it is critical to understand effective rehabilitation techniques that mitigate age-related co-morbidity and improve quality ...
Eligibility Criteria
Inclusion
- Adults aged 65-80 who do not regularly exercise
- defined as exercising less than 20 minutes twice per week
- Are willing and able to cooperate with assessments and interventions
- Participant will be quantified at or below the "poor" range for cardiovascular fitness as assessed by a volume of oxygen (VO2) test
- 0 ml/kg/min for males
- 0 ml/kg/min for females)
- 26 on the MoCA to meet the criteria for cognitively intact
- Participants will be free from diseases affecting cognition or that would interfere with their ability to engage in aerobic exercise - including but not limited to:
- chronic heart
- liver
- kidney disease
- Free from diseases/injuries directly affecting brain functions - including but not limited to:
- significant closed head injury
- open intracranial wounds
- stroke
- epilepsy
- degenerative diseases of the nervous system
- All subjects will speak English as a primary language and will have at minimum a high school diploma so that behavioral/cognitive measures reflect effects of aging and aerobic exercise and not unfamiliarity with the English language or a lack of education
Exclusion
- Potential participants with major psychiatric disorder - including but not limited to:
- psychosis
- major depression
- bipolar disorder
- Individuals with ongoing drug or alcohol abuse and severe hypertension (systolic BP \> 200 or diastolic BP \> 110 mm Hg or subjects taking three or more antihypertensive medications
- Participants must not have conditions incompatible with MRI - including but not limited to:
- ferrous metal implants
- cardiac pacemakers or similar devices
- claustrophobia
- morbid obesity
- Persons engaging in significant skilled manual movements regularly will be excluded so that behavioral/motor measures reflect the effects of age and aerobic exercise and not the effects of frequent practice
Key Trial Info
Start Date :
April 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03803904
Start Date
April 1 2019
End Date
May 1 2026
Last Update
May 23 2025
Active Locations (1)
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1
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States, 30033-4004