Status:
COMPLETED
Importance of Neurogenic Inflammation in the Angiogenic Response of the Dental Pulp as a Defensive Response
Lead Sponsor:
Institucion Universitaria Colegios de Colombia
Collaborating Sponsors:
Universidad Cooperativa de Colombia seccional Pasto
Conditions:
Occlusal Trauma
Orthodontic Appliance Complication
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
This study measures SP, CGRP and VEGF expression in human dental pulp under occlusal trauma induced by occlusal interferences under moderate orthodontic forces or under a combination of occlusal traum...
Detailed Description
Substance P (SP) and calcitonin gene-related peptide (CGRP) are neuropeptides that are assembled in the cell bodies of the trigeminal nerve and are transported through axonal flow to the nerve endings...
Eligibility Criteria
Inclusion
- Teeth in normal masticatory function
- Complete root development verified clinically and radiographically
Exclusion
- Patients under medication
- Smokers
- Pregnant women were excluded
- Teeth with caries
- Teeth with restaurations,
- Teeth with previous orthodontic treatment
- Teeth with periodontal disorders
- Teeth with parafunctional habits.
Key Trial Info
Start Date :
July 2 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 12 2015
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03804034
Start Date
July 2 2013
End Date
January 12 2015
Last Update
April 26 2019
Active Locations (1)
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1
Facultad de Odontologia, Unicoc
Bogotá, Colombia