Status:
COMPLETED
Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation
Lead Sponsor:
Fujian Medical University Union Hospital
Conditions:
Lung Cancer
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
To observe the effect of compliance guided an optimal Positive End-Expiratory Pressure（PEEP）on arterial oxygenation and intrapulmonary shunt during one-lung ventilation(OLV)，and discuss the lung prote...
Detailed Description
Sixty patients undergoing thoracic surgery were randomly allocated to the study or control group.Patients were monitored for electrocardiogram, pulse oximetry, and non-invasive blood pressure,20 gauge...
Eligibility Criteria
Inclusion
- Aged 18 yr to 65 yr
- Body mass index(BMI)18-28kg/m2
- American Society of Anesthesiologists Physical Status Classifications I to II
- Normal cardiac and pulmonary function
- Diagnosed with uncomplicated lung cancer and was to receive video-assist thoracoscopic lobectomy under general anesthesia.
Exclusion
- Forced expiratory volume at one second/forced vital capacity \<70%
- Asthma
- Chronic obstructive pulmonary disease
- Acute lung infection
- Past history of thoracic surgery
- Cardiac,hepatic,renal and endocrine diseases
- Preoperative glucocorticoid medication
- Preoperative chemotherapy
- Peripheral oxygen saturation（SpO2） kept below 90% for more than 10 minutes during operation
- Blood transfusion during operation
- Duration of one-lung ventilation less than an hour
- Occurrence of severe complications like allergic shock
Key Trial Info
Start Date :
June 14 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2018
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT03804398
Start Date
June 14 2018
End Date
November 1 2018
Last Update
January 15 2019
Active Locations (1)
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1
FujianUnionHospital
Fuzhou, Fujian, China