Status:
TERMINATED
Cognition and Neuroplasticity Sedentary Adults After 8 Weeks of Aerobic Exercise
Lead Sponsor:
University of Miami
Collaborating Sponsors:
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Sedentary Behavior
Eligibility:
All Genders
55+ years
Phase:
NA
Brief Summary
The overall goal of the proposed study is to evaluate the effects of an 8-week aerobic exercise program on cognition and determine the relationship between cognitive improvements and Transcranial Magn...
Detailed Description
The overall goal of the proposed study is to evaluate the effects of an 8-week aerobic exercise program on cognition and determine the relationship between cognitive improvements and neuroplasticity. ...
Eligibility Criteria
Inclusion
- age ≥ 55years
- no clinically detectable cognitive impairment (MoCA score ≥ 24 and Clinical Dementia Rating (CDR) score of 0)
- low activity level (individuals who do not engage in regular exercise, or currently exercise once a week or less)
- primary language is English
Exclusion
- any unstable medical condition (i.e.: uncontrolled hypertension or uncontrolled diabetes)
- medical contraindication to physical exercise
- contraindication to TMS Neuroplasticity testing, as per the TMS Safety Guidelines.
- History of fainting spells of unknown or undetermined etiology that might constitute seizures
- History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy
- Any current history of a psychiatric illness
- No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
- The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other Central Nervous System (CNS) active drugs.
- The published TMS guidelines review medications to be considered with TMS.
- Any metal in the brain, skull or elsewhere unless approved by the responsible MD
- Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
- Intracranial lesion
- Substance abuse or dependence within the past six months
- Pregnant women
- Vulnerable populations such as prisoner's
- People unable to consent themselves
- Subjects who, in the Investigator's opinion might not be suitable for the study
Key Trial Info
Start Date :
March 8 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 28 2021
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT03804528
Start Date
March 8 2019
End Date
May 28 2021
Last Update
September 19 2024
Active Locations (1)
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1
University of Miami Miller School of Medicine
Miami, Florida, United States, 33136