Status:
UNKNOWN
Can Brisk Walking Combined With Ingestion of a Lipid-lowering Drug Improve Fat Metabolism in Muscle?
Lead Sponsor:
Liverpool John Moores University
Collaborating Sponsors:
Diabetes UK
Liverpool University Hospitals NHS Foundation Trust
Conditions:
Pre Diabetes
Eligibility:
All Genders
25-55 years
Phase:
NA
Brief Summary
Briefly, participants will be assessed for their eligibility for the study using an oral glucose tolerance test, which involves drinking a sugary drink followed by a series of small blood samples. If ...
Detailed Description
The accumulation of fat in skeletal muscle is linked with insulin resistance in obesity and T2D. However, fat also accumulates in the muscle of lean, healthy people, but they remain insulin sensitive....
Eligibility Criteria
Inclusion
- Aged 25-55 years
- Overweight or obese (BMI \>28 kg.m-2)
- Have prediabetes
- Not currently using any anti-diabetes medication
- Physically inactive (performing less than two 30 min structured exercise sessions per week for the last year)
- Not pregnant (or intending to get pregnant during the study) or currently breast feeding
- Pre-menopausal
- Not currently involved in a weight loss programme or using weight loss medication
Exclusion
- Involved in regular exercise (engaged in more than 2 sessions of structured exercise of \>30 min per week)
- Currently using anti-diabetes medication (e.g. insulin, metformin)
- Currently using niacin/vitamin B3 supplements
- Pregnant or breast feeding
- Currently engaged in active weight loss programmes or using weight loss medication
- Diagnosed with chronic kidney disease
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03804892
Start Date
October 1 2019
End Date
December 1 2024
Last Update
January 3 2024
Active Locations (1)
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1
Liverpool John Moores University
Liverpool, Merseyside, United Kingdom, L18 8EU