Status:
COMPLETED
Effect of a Higher Blood-pressure on Right Ventricular Function
Lead Sponsor:
Frisius Medisch Centrum
Conditions:
Blood Pressure
Right Ventricular Dysfunction
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Right ventricular (RV) dysfunction in cardiac surgery is an independent risk factor for morbidity and mortality. Raising the systemic blood pressure with norepinephrine seems to have a positive influe...
Detailed Description
Goal: To demonstrate differences in RV function by raising the systemic blood pressure with norepinephrine. Study design: randomized controlled trial Study population: 78 postoperative cardiac surger...
Eligibility Criteria
Inclusion
- post operative cardiac surgery patients, full sternotomy
- admission at ICU
- informed consent
- right ventricular monitoring by pulmonary artery catheter.
- RVEF \<30% + MAP ≤ 65mmHg
Exclusion
- no informed consent
- acute surgery
- Off pump cardiac surgery
- Severe tricuspid insufficiency
- Allergy to norepinephrine
- Severe left ventricular hypertrophy with systolic anterior movement
- Chronic use of alpha-blockers
- Irregulair heart rhythm
- Surgical reasons to maintain a low blood pressure.
Key Trial Info
Start Date :
March 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 25 2020
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT03806582
Start Date
March 1 2019
End Date
May 25 2020
Last Update
May 27 2020
Active Locations (1)
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1
Medical Center Leeuwarden
Leeuwarden, Netherlands, 8904 BR