Status:
COMPLETED
Isomaltulose VS Sucrose - Postprandial Effect on Incretin Profile and Second Meal Effect
Lead Sponsor:
German Institute of Human Nutrition
Collaborating Sponsors:
Beneo GmbH
Conditions:
Diabetes Mellitus, Type 2
Metabolic Syndrome
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
This study evaluates the different postprandial effect of isomaltulose and sucrose on the incretin profile and as an determinant for the second meal effect. In this nutritional intervention study, he...
Detailed Description
Isomaltulose is a natural occurring disaccharide with a similar structure to sucrose. It is composed of glucose and fructose, but is linked by an α-1,6-glycosidic bond instead of α-1,2. Due to its bin...
Eligibility Criteria
Inclusion
- for T2DM patients: insulin-independent
- for healthy subjects: at least 1 component of the metabolic syndrom:
- Body mass index (BMI) ≥ 30 kg/m²
- Waist-hip ratio (WHR) ≥ 85 for women and ≥ 90 for men
- hypertension
- dyslipidemia
- glucose / insulin intolerance
Exclusion
- medications: intake of medications which influence glucose metabolism
- alcohol / drug abuse
- physical diseases: endocrinological, malign, serious cardiovascular diseases
- acute / chronic communicable disease
- psychic diseases
Key Trial Info
Start Date :
November 5 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 30 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03806920
Start Date
November 5 2016
End Date
July 30 2019
Last Update
June 24 2020
Active Locations (1)
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1
German Institute of Human Nutrition
Potsdam, Brandenburg, Germany, 14458