Status:
COMPLETED
Mini Fluid chAlleNge and End-expiratory Occlusion Test and to Assess flUid responsiVEness in opeRating Room
Lead Sponsor:
Humanitas Clinical and Research Center
Conditions:
Hemodynamic Instability
Anesthesia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
End-expiratory occlusion test (EEOT) has been previously successfully tested in surgical patients, consisting of the interruption of the mechanical ventilation for 30 seconds, and in the evaluation of...
Detailed Description
Targeted fluid therapy has received increasing attention in the management of patients showing acute circulatory failure in both intensive care unit (ICU) and operating room (OR), aiming at preventing...
Eligibility Criteria
Inclusion
- All elective adults (age \> 18 years) consecutive patients scheduled for elective abdominal surgery requiring invasive arterial monitoring and scheduled in those operating rooms equipped with ventilators having an expiratory-hold function.
- The preoperative exclusion criteria were 1) any recurrent cardiac arrhythmia; 2) known reduced left (ejection fraction \< 30%) or right (systolic peak velocity of tricuspid annular motion \< 0.17 m/s) ventricular systolic function; Body Mass Index \> 35; 4) chronic obstructive pulmonary disease classified as GOLD ≥ 2. Once enrolled, the patient can be additionally excluded because of the occurrence of one of the following intraoperative conditions: 1) significant bleeding (more than 500 ml in ½ hour); 2) persistent and/or recurrent extrasystoles; 3) persistent low quality of the arterial signal despite optimization of the signal (see further).
Exclusion
Key Trial Info
Start Date :
February 27 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 16 2020
Estimated Enrollment :
103 Patients enrolled
Trial Details
Trial ID
NCT03808753
Start Date
February 27 2019
End Date
January 16 2020
Last Update
January 18 2020
Active Locations (3)
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1
Humanitas Research Hospital
Rozzano, Milano, Italy, 20089
2
Careggi University Hospital
Florence, Tuscany, Italy, 50134
3
Maggiore della Carità University Hospital
Novara, Italy, 28100