Status:
COMPLETED
Efficacy of Pregabalin for the Treatment of Acute Herpetic Neuralgia
Lead Sponsor:
B.P. Koirala Institute of Health Sciences
Collaborating Sponsors:
University Grants Commission
Conditions:
Herpes Zoster
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
All eligible Herpes Zoster patients will be randomized into two groups. Group 1 will be the treatment group receiving Pregabalin 75 mg twice daily for 4 weeks in addition to other routine treatment. W...
Detailed Description
This study wants to see the role of Pregabalin in acute herpetic neuralgia pain reduction and for the prevention of post herpetic neuralgia incidence as compared to placebo group. For this purpose, al...
Eligibility Criteria
Inclusion
- Patients of HZ presenting within 72 hours of onset of rash,
- With pain score 40 or above on 100 mm pain Visual Analogue Scale at the screening visit,
- Giving written consent for the study.
- Age between 18-70 years
Exclusion
- HZ presenting after 72 hours of onset
- Pain score less than 40 at baseline
- Who took the stable doses of oral analgesics like: NSAIDs, acetaminophen, opioids and antidepressant within six hours of screening visit
- Using Pregabalin and Gabapentin within last 72 hours
- Nerve block therapy within the last 48 hours
- History of hypersensitivity to the drug or its ingredients
- Use of topical medications within 12 hours
- Unable to come for follow up because of severe systemic illness
- Significant hepatic and renal disease,
- Bed ridden patients or those who are physically unfit for follow up visits.
- Ethically considered vulnerable members- pregnant/lactating mothers/newborn/children below 12 years /physically or mentally challenged individuals/HIV/ AIDS/IV drug users
Key Trial Info
Start Date :
July 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2019
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT03809702
Start Date
July 15 2018
End Date
December 30 2019
Last Update
October 14 2020
Active Locations (1)
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1
B P Koirala Institute of Health Sciences
Dharān, Koshi, Nepal, 7053