Status:
COMPLETED
Can the Health Benefits of a Walking-based Exercise Programme be Enhanced by Co-ingestion of a Lipid-lowering Drug?
Lead Sponsor:
Liverpool John Moores University
Collaborating Sponsors:
Diabetes UK
Liverpool University Hospitals NHS Foundation Trust
Conditions:
Pre-diabetes
Eligibility:
All Genders
25-50 years
Phase:
NA
Brief Summary
Study investigates the hypothesis that an exercise programme of steady walking will have larger effects on insulin sensitivity and glycemic control when combined with Acipimox intake prior to each exe...
Detailed Description
Study 3 investigates the hypothesis that an exercise programme of steady walking will have larger effects on insulin sensitivity and glycaemic control when combined with Acipimox intake prior to each ...
Eligibility Criteria
Inclusion
- BMI \>28 kg.m-2
- Pre-diabetic
- Not currently using any anti-diabetes medication
- Physically inactive (performing less than two 30 min structured exercise sessions per week for the last year)
- Not pregnant or currently breast feeding
- Pre-menopausal
- Not currently involved in a weight loss programme or using weight loss medication
Exclusion
- Involved in regular exercise (engaged in more than 2 sessions of structured exercise of \>30 min per week)
- Currently using anti-diabetes medication (e.g. insulin, metformin)
- Currently using niacin/vitamin B3 supplements
- Pregnant or breast feeding
- Currently engaged in active weight loss programme or using weight loss medication
- Diagnosed with chronic kidney disease
Key Trial Info
Start Date :
January 6 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2023
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03809793
Start Date
January 6 2020
End Date
July 31 2023
Last Update
January 3 2024
Active Locations (1)
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1
Liverpool John Moores University
Liverpool, Merseyside, United Kingdom, L18 8EU