Status:
RECRUITING
Closed-loop tDCS in Patients in Minimally Conscious State
Lead Sponsor:
University of Liege
Conditions:
Minimally Conscious State
Eligibility:
All Genders
16-75 years
Phase:
NA
Brief Summary
This research will test a closed-loop system using EEG-arousal measures (spectral entropy) to define the best moment of the day for application of transcranial direct current stimulation (tDCS) in pat...
Detailed Description
During the last 20 years, with the rediscovering and development of noninvasive brain stimulation (NIBS); techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic st...
Eligibility Criteria
Inclusion
- CNS medication stable for at least a week,
- Stable diagnosis of MCS (no diagnosis change based on 2 CRS-R performed within 1 week).
- Adult (16 years old - 75 years old)
- \> 28 days post injury
Exclusion
- open craniotomies,
- VPS under the stimulated area (prefrontal cortex),
- pacemaker,
- metallic cerebral implant, according to safety criteria for transcranial electric stimulation,
- severe medical conditions that might influence clinical diagnosis and EEG activity (e.g., severe hepatic insufficiency or renal failure, or sub-continuous or abundant epileptiform discharges on standard EEG recordings).
Key Trial Info
Start Date :
August 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03810079
Start Date
August 1 2019
End Date
December 1 2024
Last Update
April 29 2024
Active Locations (1)
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1
University Hospital of Liege
Liège, Belgium, 4000