Status:
COMPLETED
The Use of Fractionated Exhaled Nitric Oxide in the Diagnosis and Assessment of Disease Activity of Eosinophilic Esophagitis (Pilot)
Lead Sponsor:
The University of Texas Health Science Center, Houston
Conditions:
Eosinophilic Esophagitis
Eligibility:
All Genders
5-18 years
Brief Summary
The purpose of the study is to evaluate of the relationships between fractionated exhaled nitric oxide, disease activity, and symptom severity in patients with eosinophilic esophagitis compared to tho...
Eligibility Criteria
Inclusion
- Pediatric patient who will undergo esophagogastroduodenoscopy with biopsies at Children's Memorial Hermann Hospital, as part of the standard of care in the evaluation of EoE
- Able to perform the single-breath exhalation for the hand-held analyzer, NIOX MINO (Aerocrine, Sweden)
- Signed informed consent by a parent or legal guardian
- Signed assent form by the child/adolescent subjects 7-18 years of age
Exclusion
- Past medical history of asthma, allergic rhinitis, IBD, parasitic infection, hay fever and any exposure to smoking (including secondhand smoke) because these disorders are known to affect the FeNO levels
- Active respiratory tract infections at the time of FeNO evaluation because this can affect the result of the FeNO as well
- Asthma questionnaire and/or Spirometry test consistent with asthma
Key Trial Info
Start Date :
January 31 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2020
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03812575
Start Date
January 31 2019
End Date
June 1 2020
Last Update
May 10 2024
Active Locations (1)
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1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030