Status:
COMPLETED
Effects of Brain Stimulation on Higher-Order Cognition
Lead Sponsor:
University of California, Davis
Conditions:
Schizophrenia
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated b...
Eligibility Criteria
Inclusion
- Participants must be able to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks.
- All subjects must have the ability to give valid informed consent.
- Inclusion Criteria for Patients with Schizophrenia Only:
- Diagnosis of schizophrenia, schizophreniform or schizoaffective disorder
- No medication changes in the prior month
- No medication changes anticipated in the upcoming month
- Stable outpatient or partial hospital status
- Normal IQ (\>70; IQ will be measured by administering the Wechsler Abbreviated Scale of Intelligence (WASI) test)
Exclusion
- Pacemakers
- Implanted electrical (brain and spinal) stimulators
- Implanted defibrillator
- Metallic implants
- Skin damage or skin conditions such as eczema at the sites where electrodes will be placed
- Hair styles hindering the placement of electrodes
- Cranial pathologies
- Head trauma
- Epilepsy
- Mental retardation
- Any known history of neurological disorders (including epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, cerebral palsy, any DSM-5 axis I psychiatric disorder (for healthy control subjects), autism)
- Uncorrected vision problems that would hinder cognitive testing (this also pertains to subjects with color blindness in tasks where discriminating colored objects/items is necessary for successful performance)
- Pregnancy
- Substance dependence in the past six months
- Substance abuse in the past month
Key Trial Info
Start Date :
May 22 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2025
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT03814967
Start Date
May 22 2019
End Date
May 31 2025
Last Update
July 29 2025
Active Locations (1)
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1
Imaging Research Center
Sacramento, California, United States, 95817