Status:
COMPLETED
Siderophore-profile in Allergic and Non-allergic Subjects
Lead Sponsor:
Medical University of Vienna
Conditions:
Allergy
Healthy
Eligibility:
All Genders
18-60 years
Brief Summary
This study aims to profile the siderophore-content in the human gut from allergic and non-allergic subjects and to assess their contribution in iron homeostasis.
Detailed Description
Iron is an essential nutrient for the majority of commensal bacteria, which commonly secrete siderophores to liberate iron from their surroundings. In several studies, a misbalanced microbiota has bee...
Eligibility Criteria
Inclusion
- allergic and non-allergic volunteers
Exclusion
- Patients will not be considered for the study if they have co-morbidities such as diabetes mellitus, disorders of the liver including hemochromatosis or kidney, autoimmune or metabolic diseases and malignancy or if they use of medications (e.g. antibiotics, PPIs) that influence the iron, inflammatory or microbial status. Further exclusion criteria are pregnancy, lactation; veganism, zinc, and iron supplementation and smoking. Volunteers will be asked to cease blood donation for at least three months' before recruitment and to cease other supplements for at least two weeks, e.g. vitamins, fish oil or minerals (other than zinc and iron).
Key Trial Info
Start Date :
December 12 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 12 2021
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT03815981
Start Date
December 12 2018
End Date
December 12 2021
Last Update
March 15 2023
Active Locations (1)
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1
Medical University of Vienna
Vienna, Austria, 1090