Status:
COMPLETED
Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Conditions:
Cerebrovascular Circulation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cerebral autoregulation (CA) is the mechanism by which the brain vasculature maintains constancy of cerebral blood flow (CBF). Reliable direct measurements of CBF at different blood pressure levels ar...
Eligibility Criteria
Inclusion
- ASA-I or ASA-II, willing and able to give written informed consent, scheduled for elective, non-cardiothoracic surgery under general anaesthesia and age 18 years and above.
Exclusion
- Patient related
- Unable/ unwilling to participate
- ASA-III or higher
- Age \< 18 years
- History of: uncontrolled hypertension, diabetes, Parkinson's disease, uncontrolled cardiac arrhythmia, Pure autonomic failure (formerly called idiopathic orthostatic hypotension), Multiple system atrophy with autonomic failure (formerly called Shy-Drager syndrome), Addison's disease and hypopituitarism, pheochromocytoma, peripheral autonomic neuropathy (e.g., amyloid neuropathy, idiopathic autonomic neuropathy), known cardiomyopathy, extreme left ventricle hypertrophy or ejection fraction \< 30%, proven or suspected allergy for any of the medication used during induction of anaesthesia, malignant hyperthermia.
- Unability to record transcranial Doppler ultrasound due to anatomical variance (\~5% of population)
- Contra-indications for intravenous or inhalational anaesthesia.
- Contra-indications for phenylephrine: severe hypertension, peripheral vascular illness, severe hyperthyroidism
- Simultaneous use of MAO-inhibitors, dopaminergic or vasoconstrictor ergot alkaloids (bromocriptine, cabergoline, pergolide, ergotamine, methylergometrine, methysergide), linezolid, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, digoxin, quinidine, oxytocin.
- Surgery related
- Day case surgery
- Laparoscopy with CO2 insufflation
- Extreme positioning during surgery (head-down/up tilt, lateral decubitus position, prone)
- Surgery \< 60 minutes.
Key Trial Info
Start Date :
January 7 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 23 2019
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT03816072
Start Date
January 7 2019
End Date
September 23 2019
Last Update
May 27 2021
Active Locations (1)
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1
Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands, 1105 AZ