Status:
COMPLETED
Ketone Supplementation, Glucose Control, and Cardiovascular Function
Lead Sponsor:
University of British Columbia
Conditions:
Hyperglycemia, Postprandial
Overweight and Obesity
Eligibility:
All Genders
30-69 years
Phase:
NA
Brief Summary
Post-prandial hyperglycemic excursions induce a cascade of deleterious effects on the body, including increased inflammation, production of reactive oxygen species, and impaired cardiovascular functio...
Eligibility Criteria
Inclusion
- Elevated waist circumference (\>102 cm for males, \>88 cm for females) and/or Obesity (BMI \> 30 kg/m2) and/or Diagnoses of prediabetes based on A1C (5.7-6.4%) and/or fasting plasma glucose (5.6-6.9 mmol/l) using ADA criteria
Exclusion
- Competitively trained endurance athlete
- Actively attempting to lose weight
- History of mental illness or existing neurological disease(s)
- Previous cardiovascular events (i.e., heart attack, stroke)
- Diagnoses of diabetes
- Hypoglycemia
- Irritable bowel syndrome or inflammatory bowel disease
- Taking medication that may interfere with insulin sensitivity
- Currently following a ketogenic diet or taking ketone supplements
- Unable to commit for 2 separate 14-day trials and unable to follow a controlled diet
Key Trial Info
Start Date :
February 6 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03817749
Start Date
February 6 2019
End Date
December 31 2020
Last Update
April 28 2021
Active Locations (1)
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1
University of British Columbia, Okanagan.
Kelowna, British Columbia, Canada, V1V 1V7