Status:

RECRUITING

Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids

Lead Sponsor:

Mayo Clinic

Collaborating Sponsors:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Conditions:

Insulin Resistance

Eligibility:

All Genders

18-55 years

Phase:

NA

Brief Summary

Muscle insulin resistance is a hallmark of upper body obesity (UBO) and Type 2 diabetes (T2DM). It is unknown whether muscle free fatty acid (FFA) availability or intramyocellular fatty acid trafficki...

Eligibility Criteria

Inclusion

  • Women and Men (Women premenopausal)
  • BMI 18-27
  • Weight stable
  • Not pregnant/nursing

Exclusion

  • Ischemic heart disease
  • Atherosclerotic valvular disease
  • Smokers (\> 20 cigarettes per week)
  • Bilateral oophorectomy
  • Concomitant use of medications that can alter serum lipid profile (high dose fish oil, statins, niacin, fibrates, thiazolinediones, beta-blockers, atypical antipsychotics)
  • Lidocaine allergy

Key Trial Info

Start Date :

December 1 2018

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 1 2025

Estimated Enrollment :

60 Patients enrolled

Trial Details

Trial ID

NCT03818178

Start Date

December 1 2018

End Date

December 1 2025

Last Update

January 6 2025

Active Locations (1)

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Mayo Clinic

Rochester, Minnesota, United States, 55905