Status:
RECRUITING
Circulating Tumor DNA in Soft Tissue Sarcoma
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Mount Sinai Hospital, Canada
The Hospital for Sick Children
Conditions:
Soft Tissue Sarcoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This research study will collect blood and tumor tissue samples from patients with soft tissue sarcoma to look at circulating tumor deoxyribonucleic acid (DNA). When tumor cells are damaged or die, DN...
Detailed Description
Researchers are continually looking for ways to understand the biology of cancer such as sarcoma, and ways to improve cancer care and patient outcome. Research has shown that changes in some genes an...
Eligibility Criteria
Inclusion
- Patients must have histologically confirmed high-risk extremity or retroperitoneal liposarcoma, leiomyosarcoma and undifferentiated pleomorphic sarcoma.
- Patients must have archival tissue from the diagnostic biopsy available.
- Deemed appropriate for preoperative or postoperative radiotherapy and curative surgery following patient assessment by radiation oncologist and surgical oncologist.
- Age 18 years or older.
- Eastern Cooperative Group (ECOG) performance status ≤ 2
- Ability to understand and willing to sign a written informed consent document and comply with study requirements.
Exclusion
- Patients with benign histology
- Patients with prior malignancy within previous 5 years or concurrent malignancy other than adequately treated basal cell carcinoma of skin or carcinoma in-situ of cervix.
- Patients with planned neo-adjuvant chemotherapy.
- Patients with regional nodal disease or unequivocal metastases
- Uncontrolled inter-current illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Key Trial Info
Start Date :
January 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 17 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03818412
Start Date
January 17 2019
End Date
January 17 2025
Last Update
March 22 2024
Active Locations (1)
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1
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9