Status:
COMPLETED
Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Virginia Commonwealth University
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
21+ years
Phase:
EARLY_PHASE1
Brief Summary
Researchers have found a link between chronic obstructive pulmonary disease (COPD) and heart disease; however, a link is all they have found. Cardiovascular health in COPD is controlled by different m...
Detailed Description
The present study is designed as a double-blind, randomized, cross-over, placebo-controlled protocol. Patients with COPD will receive either resveratrol (500 mg) or placebo for 12 weeks. A comprehensi...
Eligibility Criteria
Inclusion
- Participants with a clinical diagnosis of COPD known for at least one year will be allowed to participate
- Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II to IV
- Breathing test ratio (FEV1/FVC) \<0.7
- Amount of exhaled air (FEV1) \<80% predicted after bronchodilator
- Total Lung Capacity (TLC)\>80%
- Matched healthy volunteers without COPD.
Exclusion
- FEV1/FVC\>0.7
- Clinical diagnosis of heart disease, hypertension or diabetes
- Use of vasoactive medications (nitrates, Beta blockers)
- Uncontrolled high blood pressure
- Pulmonary hypertension
- Fluid in the lungs
- Sleep apnea
- Thyroid problems
- Anemia
- Raynaud's phenomenon
- Gastrointestinal bleeding
- History of coagulopathies
- History of low platelets
- Gangrene of the digits
- Phenylketonuria
- Pregnant or women attempting to become pregnant
- In lactation
- Individuals who may not be able to read or understand the resveratrol label
Key Trial Info
Start Date :
July 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2023
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03819517
Start Date
July 1 2019
End Date
August 30 2023
Last Update
April 29 2024
Active Locations (1)
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1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298