Status:
COMPLETED
Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Chronic Obstructive Pulmonary Disease
Nasal High Flow
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to assess the effect of nasal high flow oxygen therapy on regional function measured by volumetric computed tomography, in patients with chronic obstructive pulmonary disease.
Detailed Description
Nasal high flow (NHF) is a non-invasive breathing therapy that is based on the delivery of heated and humidified air at flow rates that exceed peak inspiratory flow, via a large-caliber nasal cannula....
Eligibility Criteria
Inclusion
- Stable, moderate to severe COPD, defined as follows:
- Moderate: FEV1/FVC \< 0.7 or lower limit of normal, and 30 \< FEV1 ≤ 60 percent predicted; Severe: FEV1/FVC \< 0.7 or lower limit of normal, and FEV1 ≤ 30 percent predicted
- Indication for CT imaging as part of routine workup.
- Written informed consent signed
Exclusion
- Acute disease condition such as infection, respiratory or cardiac failure
- Persons referred to in Articles L1151-5 to L1151-8 and L1122-1-2 of the French Public Health Code: Declared pregnant, parturient or lactating, persons deprived of their liberty by judicial or administrative decision, minors, adults who are legally protected or unable to express consent, etc.
- Evolving neoplastic disease
- Patient without social security health care coverage
- Subject in an exclusion period from another study
- Any contraindication to NHF such as nasal or upper airway bleeding, secretion, tumor, recent surgery; cervical, nasal or skull fracture.
Key Trial Info
Start Date :
December 6 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 18 2019
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT03821311
Start Date
December 6 2018
End Date
June 18 2019
Last Update
December 27 2019
Active Locations (1)
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1
University Hospital Grenoble
Grenoble, Isère, France, 38000