Status:
COMPLETED
Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock
Lead Sponsor:
Southeast University, China
Conditions:
Septic Shock
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.
Detailed Description
This prospective, double-blind, randomized, controlled trial enrolled septic shock patients admitted to the intensive care unite of a tertiary teaching hospital. We randomly assigned the enrolled pati...
Eligibility Criteria
Inclusion
- Septic shock
- A dose of norepinephrine (\>15ug/min)
- Age ≥18 and ≤80 years old
- Signing Informed Consent
Exclusion
- Meet the inclusion criteria for more than 12 hours
- Clinician judges that corticosteroid therapy should not be used
- Pregnant
- Uncontrolled malignancy
- Glucocorticoid therapy was used within seven days before admission.
- Expected death within 24 hours
- The sublingual microcirculation cannot be measured
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2020
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT03821714
Start Date
February 1 2019
End Date
January 30 2020
Last Update
October 10 2023
Active Locations (1)
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1
Nanjing Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China, 210000