Status:
COMPLETED
Hyperventilation in Patients With Traumatic Brain Injury
Lead Sponsor:
University of Zurich
Conditions:
Head Injury Trauma
Hyperventilation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Elevated intracranial pressure is a dangerous and potentially fatal complication after traumatic brain injury. Hyperventilation is a medical intervention to reduce elevated intracranial pressure by in...
Detailed Description
In patients with severe traumatic brain injury (TBI), and with intracranial pressure-monitoring, brain tissue oxygen tension and/or microdialysis probes hyperventilation-tests are performed in the acu...
Eligibility Criteria
Inclusion
- nonpenetrating traumatic brain injury
- Glasgow coma scale \<9 at presentation
- Intracranial pressure monitoring
- brain tissue oxygen tension monitoring and/or microdialysis monitoring
- invasive mechanical ventilation with FIO2 \<60% and PEEP \<15 mbar
Exclusion
- decompressive craniectomy
- pregnancy
- pre-existing neurological disease
- previous traumatic brain injury
- acute cardiovascular disease
- severe respiratory failure
- acute on chronic liver disease
- sepsis
- failure to obtain satisfactory bilateral TCCD signals
- persisting hypovolemia or hemodynamic instability
Key Trial Info
Start Date :
May 20 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 2 2017
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03822026
Start Date
May 20 2014
End Date
May 2 2017
Last Update
January 30 2019
Active Locations (1)
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1
University Hospital Zurich
Zurich, Switzerland, 8006