Status:
COMPLETED
Probiotic Supplementation on Weight Loss
Lead Sponsor:
Mayo Clinic
Conditions:
Bariatric Surgery Candidate
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The investigators are trying to better understand how bariatric surgery leads to weight loss, and the role of bacteria that live in the gut in making this happen.
Detailed Description
The investigators are interested in seeing how a probiotic, which is a dietary supplement containing large amounts of 'good' bacteria, can influence the make-up of the gut bacterial population and wha...
Eligibility Criteria
Inclusion
- All subjects who are \> 18 and \< 65 years of age recruited from the Mayo Clinic bariatric surgery clinic
- Will also meet one of the National Institute of Health's criteria for bariatric surgery, i.e. body mass index (BMI) \> 40 kg/m2 or BMI \> 35 kg/m2 with significant weight-related comorbidities.
- Patients will be eligible if they are not on chronic antibiotic therapy and without active systemic illness.
Exclusion
- Patients with type 1 or 2 diabetes will be excluded due to the known pre-existing changes in the gut microbiome in this population. All patients will not have had exposure to probiotics, prebiotics or antibiotics in the preceding 4 weeks.
- Patients with allergy to antibiotics precluding the use of standard peri-operative antibiotics (cefazolin and metronidazole) will be excluded.
Key Trial Info
Start Date :
January 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 28 2021
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT03832439
Start Date
January 17 2019
End Date
April 28 2021
Last Update
February 21 2022
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905