Status:
UNKNOWN
Annexin Imaging in Dissection of the Descending Aorta
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Chronic Dissection of Thoracic Aorta (Disorder)
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The relationship between the presence of a partial thrombus and aortic dilation after type B dissection has recently been reported. The originality lies in the idea of imaging thrombus activity to pre...
Detailed Description
To establish the proof of concept in humans of the link between the intensity of 99mTc-annexin V-128 binding in the descending thoracic aorta and the progression of aortic diameter in patients with ty...
Eligibility Criteria
Inclusion
- patient whose age is ≥ 18 years old
- any patient seen more than 6 months and less than 5 years after a dissection involving the descending aorta at Bichat Hospital, whether it is a dissection of the descending aorta alone or a dissection of the ascending aorta extended to the descending aorta
- dissection of the uncomplicated descending thoracic aorta: not requiring surgery or stent implantation within the first 6 months after acute dissection
- effective contraception for women of childbearing age
Exclusion
- scheduled procedure for dissection of the descending aorta
- contraindication to aortic CT with injection of contrast media: renal failure with creatinine clearance \<30 ml/min or creatinine \>200 µmol/l; allergy to contrast media
- history of surgery or stent implantation in the descending thoracic aorta
- pregnant or breastfeeding women
- patient under guardianship or trusteeship
- non affiliation to social security or CMU (beneficiary or assignee)
- patient refusal to participate in the study
Key Trial Info
Start Date :
May 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
83 Patients enrolled
Trial Details
Trial ID
NCT03832582
Start Date
May 1 2019
End Date
December 31 2024
Last Update
February 11 2019
Active Locations (1)
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1
Service de Cardiologie - Hôpital Bichat Claude Bernard
Paris, France, 75018