Status:
COMPLETED
Molecular Diagnosis of Idiopathic Interstitial Pneumonias: a Prospective Study
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborating Sponsors:
Western University, Canada
Conditions:
Idiopathic Interstitial Pneumonia
Idiopathic Pulmonary Fibrosis
Eligibility:
All Genders
18+ years
Brief Summary
Molecular diagnosis of idiopathic interstitial pneumonias is an innovative way to potentially improve the diagnostic accuracy of surgical lung biopsies (SLBs), introducing molecular classifiers of idi...
Detailed Description
Aim of the study This is a prospective, observational trial to collect samples of SLB, extract RNA, analyze transcriptional profiles by microarray, and validate previously identified gene expression p...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Chronic interstitial lung disease not caused by connective tissue disease, drug-induced toxicity or environmental occupational or domestic exposures. These criteria equal to a diagnosis of idiopathic interstitial pneumonia (IIP).
- High resolution chest CT scan not consistent with an idiopathic pulmonary fibrosis pattern, therefore requiring a surgical lung biopsy to clarify the exact diagnosis of IIP.
- No contraindications to undergo a surgical lung biopsy (advanced disease stage; significant cardiac disease; significant obesity; or associated pulmonary hypertension).
- Patient able to provide informed consent.
- Exclusion criteria:
- Chronic interstitial lung disease caused by connective tissue disease, drug-induced toxicity or environmental occupational or domestic exposures.
- High resolution chest CT scan consistent with an idiopathic pulmonary fibrosis pattern, therefore not requiring a surgical lung biopsy.
- Contraindications to undergo a surgical lung biopsy (advanced disease stage; significant cardiac disease; significant obesity; or associated pulmonary hypertension).
Exclusion
Key Trial Info
Start Date :
June 28 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 17 2024
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT03836417
Start Date
June 28 2019
End Date
October 17 2024
Last Update
March 11 2025
Active Locations (1)
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1
London Health Science Centre
London, Ontario, Canada, N6A 5W9