Status:
UNKNOWN
The Tracking Molecular Evolution for NSCLC (T-MENC) Study
Lead Sponsor:
Geneplus-Beijing Co. Ltd.
Collaborating Sponsors:
Xuanwu Hospital, Beijing
Conditions:
Lung Neoplasms
Lung Cancer
Eligibility:
All Genders
18-80 years
Brief Summary
Tumor genomic clonal evolution assessed with liquid biopsy of stage IB,II and IIIA non-small cell lung cancer patients after getting radical resection. Plasma circulating tumor DNA (ctDNA) analysis de...
Detailed Description
In the study, 200 of stage IB,II and IIIA non-small cell lung cancer patients obtained radical resection will be recruited. All the patients will receive biopsy genotype assay and ctDNA liquid biopsy....
Eligibility Criteria
Inclusion
- Provision of informed consent and assigned.
- Newly diagnosed and histological or cytological confirmed stage IB-IIIA lung adenocarcinoma or non-smoking squamous cell carcinoma patients according to the AJCC staging system.
- Expected radical resection.
- Patients expected more than 3 months of survival time.
- Willingness to comply with required protocols and give permission to use the data for clinical research and products development.
Exclusion
- Patients who want Neo-adjuvant therapy.
- Patients with T3-4N1 Pancoast tumors (superior sulcal tumors).
- Multi-station N2 non-small cell lung cancer with lymph node metastasis.
- Eastern cooperative oncology group (ECOG) performance status \> 2 after postoperative chemotherapy
- Eastern cooperative oncology group (ECOG) performance status \> 4 after postoperative targeted therapy.
- Patients must never ever has received for any history of radiotherapy/ chemotherapy/surgery before.
- Patients have other primary cancers.
- Known central nervous system metastasis.
- Patients expected less than 3 months of survival time.
- Other situations mismatch this program.
Key Trial Info
Start Date :
November 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03838588
Start Date
November 6 2018
End Date
December 31 2021
Last Update
February 12 2019
Active Locations (10)
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1
Beijing Hospital
Beijing, Beijing Municipality, China, 100005
2
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100021
3
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China, 100029
4
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100050