Status:
COMPLETED
Delineation of Reducing Clinical Target Volume for Early-stage Nasopharyngeal Carcinoma Patients
Lead Sponsor:
Sun Yat-sen University
Conditions:
Target Volume Delineation
Early-stage Nasopharyngeal Carcinoma
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
To analyze the long-term results and toxicities of the reducing clinical target volume (CTV) delineation method in early-stage nasopharyngeal carcinoma (NPC) patients treated with intensity modulated ...
Detailed Description
The investigators designed a prospective phase II study for early-stage NPC patients, and proposed a reasonable delineation method of reducing CTV according to the clinical characteristics and tumor i...
Eligibility Criteria
Inclusion
- histologically confirmed NPC (WHO II-III)
- stage I-IIb according to the 6th AJCC/UICC
- no previous treatment for NPC
- between 18 and 70 years old
- KPS ≥ 80 scores
- adequate organ function (white blood cell ≥ 4.0×109/L; absolute neutrophil count ≥ 1.5×109/L; hemoglobin ≥ 100g/L; platelet count ≥ 100×109/L; total bilirubin, aspartate aminotransferase and alanine aminotransferase ≤ 1.5X upper limit normal; and creatinine clearance rate ≥ 30 mL/min)
Exclusion
- fine-needle aspiration biopsy, incisional or excisional biopsy of neck lymph node, or neck dissection prior IMRT
- disease progression during IMRT
- presence of distant metastasis
- pregnancy or lactation
- previous malignancy or other concomitant malignant disease
Key Trial Info
Start Date :
May 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2018
Estimated Enrollment :
103 Patients enrolled
Trial Details
Trial ID
NCT03839602
Start Date
May 1 2001
End Date
January 1 2018
Last Update
February 15 2019
Active Locations (1)
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1
Cancer Center, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060