Status:
TERMINATED
Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior
Lead Sponsor:
Duke University
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute on Drug Abuse (NIDA)
Conditions:
Cigarette Smoking
Nicotine Withdrawal
Eligibility:
All Genders
21-55 years
Phase:
NA
Brief Summary
This study is designed to find out how smoking affects the way the brain responds to pleasure and how this impacts smokers' behavior. Participants will complete three sessions. The first session will ...
Eligibility Criteria
Inclusion
- Generally healthy
- Right-handed
- Smoke \>= 10 cigarettes per day
- Smoking regularly for \>= 1 year
- Carbon Monoxide (CO) \> 8 at screening (or urinary cotinine \> 100)
- Own a compatible smartphone
- Able to read and understand English
- Able to identify at least 4 pleasurable activities they do not do concurrently with smoking or associate with smoking
Exclusion
- Regular use of "roll your own" cigarettes
- Planning to quit smoking within the next 60 days
- Current or planned smoking cessation treatment
- Regular use of smokeless tobacco or other nicotine products
- Expired CO \> 80 parts per million
- Breath alcohol \> .000 at screening (re-attempts are allowed)
- Positive toxicology screen for exclusionary drugs
- Use of exclusionary medications
- Significant medical problems
- Currently breastfeeding, pregnant, or planning to become pregnant
- Enrollment in another study utilizing Spectrum cigarettes within the last 3 months
- Irregular slee-wake cycles (e.g. swing-shift work, unusual sleep patterns)
Key Trial Info
Start Date :
September 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 13 2021
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT03840694
Start Date
September 10 2019
End Date
May 13 2021
Last Update
May 20 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Duke University School of Medicine
Durham, North Carolina, United States, 27705