Status:
COMPLETED
Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department
Lead Sponsor:
Bruno Minotti
Conditions:
Analgesia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to test the additional effect of paracetamol in combination with morphine for analgesia, respectively to test/confirm an opioid sparing effect due to the additional use of...
Detailed Description
Paracetamol (acetaminophen) is widely used around the world for mild to moderate pain in all age groups. Prescription at the emergency department is very common and some studies suggest the use in alt...
Eligibility Criteria
Inclusion
- Patient with pain with Pain-score is more or equal than four in a numeric rating scale from zero to ten (i.e. indication for a treatment with morphine)
- Age over 18
- Signed informed consent. In case, patient is not able to sign the informed consent due to pain, at least verbal consent has to be provided. After pain relief, written informed consent with data and time has to be obtained
Exclusion
- Analgesia in the past last 6 hours prior to visit at the emergency department
- Current Analgesia with long-acting/extended-release drugs
- Current Analgesia with opioids
- Chronic pain syndrome
- Contraindication for either paracetamol or morphine
- Patient's refusal of paracetamol or morphine treatment
- Pregnancy or Breastfeeding
- GCS \< 13
- SpO2 \< 90% with a maximum of 4 L/Min O2
- Systolic Blood Pressure \< 90 mmHg
- "Fast Track"/Notfallpraxis patients
Key Trial Info
Start Date :
May 2 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 15 2020
Estimated Enrollment :
222 Patients enrolled
Trial Details
Trial ID
NCT03843281
Start Date
May 2 2019
End Date
October 15 2020
Last Update
October 19 2020
Active Locations (1)
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1
Kantonsspital St.Gallen
Sankt Gallen, Switzerland, 9007