Status:
TERMINATED
Pilot Study Using Amide Proton Transfer Magnetic Resonance Imaging Distinguishing Glioma
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Conditions:
Gliosarcoma
Glioma
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
This research is being done to study the pattern of changes in various parts of the magnetic resonance imaging (MRI) studies that patients have done to help plan their radiation therapy and to evaluat...
Detailed Description
Currently, all brain tumors are routinely evaluated using gadolinium contrast-enhanced (Gd-CE) MRI, in combination with T2-weighted or fluid-attenuated inversion recovery (FLAIR) MRI, which are used t...
Eligibility Criteria
Inclusion
- Pathologically Confirmed Glioma after completion of planned biopsy or resection.
- High grade glioma histologies:
- Glioblastoma
- High Grade or Malignant Glioma
- Anaplastic Astrocytoma
- Anaplastic Oligodendroglioma
- Gliosarcoma
- Mixture of any of the above histologies Low Grade Histologies
- Astrocytoma
- Grade II or low grade glioma
- Oligodendroglioma
- Mixtures of the above histologies
- Plan to undergo external radiation treatment as part of therapy
- No prior therapeutic cranial radiotherapy
- Can safely perform clinically indicated MRI (no contraindications to MRI with Gadolinium) as determined by the standard Johns Hopkins Radiation Oncology screening procedures,
Exclusion
- Patients who cannot undergo MRIs.
- Patients who are allergic to gadolinium based contrast agent
- Patients who have cardiac pacemaker or other electronic or metal implant
- Patients who have chronic kidney disease judged sufficient to exclude them from the clinically indicated contrast enhanced MRI.
- Female patients who is pregnant
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 13 2017
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT03843814
Start Date
August 1 2014
End Date
December 13 2017
Last Update
November 26 2019
Active Locations (1)
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1
The SKCCC at Johns Hopkins
Baltimore, Maryland, United States, 21287