Status:
UNKNOWN
Role of Sweetness in Glucose Regulation
Lead Sponsor:
University of Illinois at Urbana-Champaign
Collaborating Sponsors:
Washington University School of Medicine
Conditions:
Obesity
Eligibility:
All Genders
21-40 years
Phase:
NA
Brief Summary
Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, inc...
Detailed Description
The overall goal of this research is to assess the role of oral and gut sweetness signaling in postprandial glucose metabolism and to determine how acute and chronic low-calorie sweetener (LCS) consum...
Eligibility Criteria
Inclusion
- All races/ethnicities
- Habitual (\> 5 diet sodas per week) and non-habitual (≤1 diet soda or 1 packet of LCS per week) LCS consumers
- 30 ≤ BMI \<40 kg/m2
- Not severely insulin resistant (HOMA-IR2 \< 2.6)
Exclusion
- BMI \< 30 and 40\< BMI kg/m2
- HOMA-IR2\>2.6
- Irregular LCS consumers (\>1 diet sodas or packets of LCS per week but \<5)
- Current smokers or quit smoking nicotine cigarettes for less than 6 months ago
- Pregnant, breastfeeding, menopausal
- Presence of anemia : \<12g/dl for women and \<13g/dl for men
- Blood donation in the past 8 weeks
- Presence of malabsorption syndrome
- History of bariatric surgery
- Presence of inflammatory intestinal disease, liver or kidney disease
- Have diabetes (fasting glucose level \>126mg/dl or plasma glucose level 2h after glucose challenge \>200 mg/dl)
- Taking any medication that might affect glucose metabolism or the results of our study
Key Trial Info
Start Date :
April 24 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03844230
Start Date
April 24 2019
End Date
December 31 2022
Last Update
April 27 2021
Active Locations (1)
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1
University of Illinois at Urbana Champaign
Champaign, Illinois, United States, 61820