Status:
COMPLETED
Cortical Excitability Sequential Changes in Response to Transcranial Magnetic Stimulation Post Stroke
Lead Sponsor:
Cairo University
Collaborating Sponsors:
Kasr El Aini Hospital
Conditions:
Stroke, Cardiovascular
Eligibility:
All Genders
50-65 years
Phase:
NA
Brief Summary
This study was conducted to investigate the cortical excitability changes per session in response to the application of low frequency repetitive transcranial magnetic stimulation \*LF-rTMS\* on the co...
Detailed Description
Forty first ever ischemic stroke patients (3 to 6 months) were recruited and randomly assigned into two groups. Intervention for the study group consisted of 10 therapeutic( LF- rTMS) sessions, applie...
Eligibility Criteria
Inclusion
- Forty ischemic hemiparetic stroke patients aging between 50-65 years.
- Patients with first ever ischemic stroke in the territory of the middle cerebral artery (MCA) confirmed by physician with non-contrast computed tomographic (CT) or magnetic resonance imaging (MRI) scans of the brain.
- Mild to moderate motor impairment verified according to (National Institutes of Health Stroke Scale (NIHSS)-motor arm score of 1 to 15, and modified Ashworths Scale (MAS) (1 or 1+)
- Time from onset of symptoms 3 to 6 months.
- Stable vital signs with clear consciousness and proper cooperation with assessment and treatment.
- Successful measurement of the Active motor threshold (AMT) from the 'motor hot spot' of the contralesional and the ipsilesional primary motor cortex (M1) with the election of the contralateral first dorsal interosseous (FDI) muscle .
- The medical ethical committee from faculty of physical therapy, Cairo university approved the project of the study.
- All the patients or their families were given their written consent form.
Exclusion
- Patients who underwent surgical management including intravascular surgery or administration of tissue plasminogen activator .
- Patients with aphasia or apparent cognitive deficits ( eg, hand apraxia, unilateral spatial neglect) , visual field deficits or any psychiatric disorders or disturbed consciousness.
- Patients with serious general complications requiring intensive medical management (eg, pneumonia severe internal carotid artery stenosis or bilateral cerebrovascular lesion, heart failure, urinary tract infection, or malnutrition state)
- severe chronic or neurological diseases ( eg, shoulder pain; joint deformity or complete paralysis of the affected upper limb) .
- Any contraindications for rTMS in the guidelines (eg, patients with metal within the brain, such as clips for aneurysms, patients with a cardiac pacemaker, pregnant women, or a history of seizures or epilepsy).
- Use of any drugs that could have an effect on cortical excitability (eg, Anti-epileptic drugs).
- Patients previously underwent any type of treatments using transcranial magnetic stimulation.
- Refusal to sign the informed consent or could not carry out training or cooperate with assessments.
Key Trial Info
Start Date :
January 14 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 11 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03845595
Start Date
January 14 2018
End Date
November 11 2018
Last Update
February 19 2019
Active Locations (1)
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1
Faculty of physical therapy, Cairo University
Giza, Dokki, Egypt, 11432