Status:
COMPLETED
Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage
Lead Sponsor:
General Hospital of Shenyang Military Region
Conditions:
Variceal Hemorrhage
Cirrhosis, Liver
Eligibility:
All Genders
Brief Summary
Terlipressin and somatostatin/octreotide are the first-line choices for the treatment of acute variceal bleeding in liver cirrhosis. Acute kidney injury can develop in patients presenting with acute v...
Eligibility Criteria
Inclusion
- Cirrhotic patients who were admitted between January 2010 and December 2018.
- A diagnosis of acute gastrointestinal bleeding.
- Patients who received terlipressin or somatostatin/octreotide.
- Age or sex was not limited.
- Use of endoscopy was not limited.
- Comorbidity was not limited.
- Malignancy was not limited.
Exclusion
- Renal parenchymal diseases.
- Absence of baseline serum creatinine.
- Absence of serum creatinine 3-5 days after terlipressin or somatostatin/octreotide.
- Duration of terlipressin or somatostatin/octreotide was less 3 days.
- Patients who underwent transjugular intrahepatic portosystemic shunt.
- Patients who underwent surgical shunt, splenectomy with or without devascularization, or liver transplantation.
Key Trial Info
Start Date :
March 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
1682 Patients enrolled
Trial Details
Trial ID
NCT03846180
Start Date
March 1 2019
End Date
July 1 2019
Last Update
July 5 2019
Active Locations (14)
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1
Center for Liver Cirrhosis, The Fifth Medical Center of PLA General Hospital
Beijing, Beijing Municipality, China, 100039
2
Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100069
3
Liver Research Center, The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350005
4
Department of Hepatobiliary Disease, 900 Hospital of the Joint Logistics Team (formerly called Fuzhou General Hospital)
Fuzhou, Fujian, China, 350025