Status:
COMPLETED
Probiotics in Dementia
Lead Sponsor:
Medical University of Graz
Conditions:
Dementia; Alzheimer, Mixed Type (Etiology)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Dementia is associated with changes in gut microbiome composition, gut barrier dysfunction, intestinal inflammation and systemic inflammation. Probiotics are a possibility to modulate the gut-brain ax...
Detailed Description
Dementia is a disease that presents with deterioration in memory, thinking, behaviour and the ability to perform everyday activities. Worldwide 47.5 million people are affected and incidence of dement...
Eligibility Criteria
Inclusion
- Age \>18 years
- Dementia of Alzheimer type and mixed type (diagnosis by a board-certified neurologist/psychiatrist and according to ICD10)
- Mini Mental State Examination 21-26
- Stable treatment with anti-dementia drugs including phytotherapeutics (\>3 months) or no intention to start anti-dementia drugs
- Informed consent
Exclusion
- Other forms of dementia
- Inflammatory bowel diseases
- Liver cirrhosis
- Antibiotic treatment within the last 4 weeks
- Febrile illness within the last 4 weeks
- Acute hospital admission for dementia-unrelated reasons within the last 4 weeks
- Dysphagia
- Any other condition or circumstance, which, in the opinion of the investigator, would affect the patient's ability to participate in the protocol
Key Trial Info
Start Date :
June 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT03847714
Start Date
June 15 2019
End Date
December 31 2024
Last Update
February 12 2025
Active Locations (1)
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1
Medical University Graz
Graz, Austria