Status:
COMPLETED
Estradiol Patch as add-on to Antipsychotics in Patients With Schizophrenia, Schizoaffective or Schizophreniform Disorder
Lead Sponsor:
Tangent Data
Collaborating Sponsors:
Stanley Medical Research Institute
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
FEMALE
18-45 years
Phase:
PHASE3
Brief Summary
To evaluate the effects of Estradiol patches vs placebo patches as add-on to antipsychotics on psychometric performance in patients with schizophrenia, schizoaffective or schizophreniform disorder
Detailed Description
Estradiol has been shown to be an effective adjunctive treatment for schizophrenia. The estradiol hypothesis was tested in a randomized-controlled trial in which estradiol was given to women with schi...
Eligibility Criteria
Inclusion
- Female, 18-45 years of age, inclusive
- Willing and able to provide informed consent, after the nature of the study has been fully explained
- Current DSM-IV-TR diagnosis of schizophrenia, schizoaffective or schizophreniform disorder as confirmed by modified SCID.
- Total PANSS score \> 60 and (PANSS positive subscale \>15 and/or PANSS negative subscale \>15)
- Must be on a stable dose of any antipsychotic drug, for at least 2 weeks prior to the baseline visit, at doses within the PORT criteria, whenever possible. Patients receiving higher doses will have their records reviewed to insure that their dose is required and, if possible, will be stabilized on a lower dose prior to study entry.
- Patients who are physically and endocrinologically healthy,
- Inpatients or outpatients. Inpatients will be randomized 3 days or more after admission
Exclusion
- Unwilling or unable, in the opinion of the Investigator, to comply with study instructions
- Pregnant or breast-feeding
- Women who are menopausal.
- Patients treated with oral estrogen preparations containing estradiol greater than 30 mcg.
- Women who have known severe abnormalities in the hypothalamo-pituitary gonadal axis, thyroid disorders, severe medical conditions and disorders that would contraindicate estrogen use (breast cancer, migraine with aura or stroke)
- History of endometrial cancer or breast cancer, vaginal bleeding between periods, untreated endometrial hyperplasia, previous or present thrombembolism, known thrombophilic disorders, abnormal liver function tests, porphyria.
- History of 1st and 2nd grade family with breast or uterine cancer,
- Likely allergy or sensitivity to estradiol.
- Schizoaffective disorder in the manic phase.
- At significant risk of committing suicide, or in the opinion of the Investigator, currently is at imminent risk of suicide or harming others.
- Patients with a current DSM-IV substance or alcohol abuse. Patients with a history of and/or current recreational use of cannabinoids or alcohol, and/or patients who smoke cigarettes can be included.
- Concurrent delirium, mental retardation, drug-induced psychosis, or history of clinically significant brain trauma documented by CT or MRI.
- Patients receiving phenobarbital, phenytoin, carbamazepine, rifampicin, rifabutin, nevirapine, efavirenz, ritonavir and nelfinavir,or Hypericum perforatum
Key Trial Info
Start Date :
December 4 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 29 2016
Estimated Enrollment :
209 Patients enrolled
Trial Details
Trial ID
NCT03848234
Start Date
December 4 2015
End Date
July 29 2016
Last Update
May 22 2020
Active Locations (1)
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1
Clinical Psychiatric Hospital
Codru, Chișinău Municipality, Moldova, 2011