Status:
COMPLETED
Poor Sleep and Inflammation in HIV-Infected Adults
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
HIV-1-infection
Sleep Deprivation
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
People living with HIV (PLWH) often have poor sleep, which may put them at a higher risk for many chronic diseases, including cardiovascular disease. One of the mechanisms by which this may occur is v...
Detailed Description
People living with HIV infection (PLWH) are known to be at higher risk of cardiovascular disease and also have a higher prevalence of poor sleep than people who do not have HIV infection. Understandin...
Eligibility Criteria
Inclusion
- HIV positive
- On continuous anti-retroviral therapy regimen for at least 48 weeks
- CD4+ cell count greater than or equal to 200 cells/mm\^3
Exclusion
- Irregular or insufficient habitual sleep patterns
- Severe advanced or delayed sleep phase
- Primary sleep disorder
- Autoimmune disorder
- Use of immunosuppressant medications
- Use of medications impacting adenosine pathway
- Heavy caffeine use
- Active alcohol or drug abuse
- Elevated risk of adverse health effects from sleep deprivation (e.g., bipolar disorder, epilepsy, or suicidal ideation in the past 6 months)
- Pregnancy
Key Trial Info
Start Date :
November 9 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03848325
Start Date
November 9 2020
End Date
July 31 2022
Last Update
November 29 2023
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15260