Status:
UNKNOWN
Brain Imaging Biomarkers of Pathological Brain Aging in Late-life Depression
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Collaborating Sponsors:
KU Leuven
Conditions:
Depression
Eligibility:
All Genders
60+ years
Brief Summary
This study investigates the relationships and differences in PET-MRI brain imaging biomarkers of abnormal aging and behavioral measures in late life depression compared to healthy controls, and evalua...
Detailed Description
This clinical study is a combined single-center, cohort study with a (1) cross-sectional arm evaluating relationships and differences in PET-MR imaging and behavioral measures in 64 patients with late...
Eligibility Criteria
Inclusion
- Diagnosis of late-life depression according to DSM 5 (patients only)
- Age over 60 years old
- Judged to be in good physical health by the investigator on the basis of medical history
Exclusion
- history or evidence of psychiatric disease, as assessed by clinical interview (healthy controls only).
- history of major other neurological disorder, or major internal pathology that may make him/her unfit for participation according to the interpretation by the investigator (including cardiac, lung, haematological, gastro-intestinal disorders or cancer);
- current user (including ''recreational use'') of any illicit drugs,including cannabis, or has a history of drug or alcohol abuse;
- had exposure to ionizing radiation (\> 1 mSv) in other research studies within the last 12 months;
- has a contra-indication for MRI scanning;
- suffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures; cannot lie still for 60 minutes inside the scanner;
- does not understand the study procedures
- unwilling or unable to perform all of the study procedures, or is considered unsuitable in any way by the principal investigator;
- underwent ECT within the last 3 months before enrollment (patients)
Key Trial Info
Start Date :
June 19 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
128 Patients enrolled
Trial Details
Trial ID
NCT03849417
Start Date
June 19 2019
End Date
December 1 2024
Last Update
June 25 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UZ Leuven
Leuven, Belgium