Status:
ENROLLING_BY_INVITATION
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Brain Metabolism
Eligibility:
All Genders
18-60 years
Brief Summary
Investigators propose to develop hyperpolarized \[13C\]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesi...
Detailed Description
Investigators will perform a pilot study to test the translational feasibility by evaluating sensitivity and repeatability of hyperpolarized \[1-13C\]pyruvate and \[2-13C\]pyruvate in healthy human su...
Eligibility Criteria
Inclusion
- 18 through 60 years of age.
- Healthy, with no neurological abnormalities.
- Ability to understand and the willingness to sign a written informed consent.
- All races and ethnicities will be included; subjects must be able to read and speak the English language.
Exclusion
- Metallic foreign bodies on the scalp or cranium which may interfere with MRI acquisitions
- Major debilitating neurological disease including, but not limited to, stroke, CVA, dementia and tumor that would limit compliance with study requirements
- Under influence of illicit drugs which are known to alter brain physiology/metabolism including, but not limited to cocaine, lysergic acid diethylamide (LSD), and marijuana at the time of MRI/MRSI scanning.
- Under influence of antiepileptic drugs at the time of MRI/MRSI scanning.
- Any contraindication per MRI Screening Form including
- Implants contraindicated at 3T, pacemakers
- Implantable Cardioverter Defibrillator (ICD)
- Claustrophobia
- Medically unstable including
- Heart failure
- Severe left ventricular outflow tract (LVOT) obstruction
- Unstable angina
- Pregnancy
- Lactating
Key Trial Info
Start Date :
July 30 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT03849963
Start Date
July 30 2020
End Date
December 31 2026
Last Update
March 6 2025
Active Locations (1)
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1
UT Southwestern - Advanced Imaging Research Center
Dallas, Texas, United States, 75390