Status:
TERMINATED
The Impact of Fluid Volume Shifts on Upper Airway Collapse and Obstructive Sleep Apnea in Surgical Patients
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Canadian Lung Association
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
18+ years
Brief Summary
The objective of this study is to examine the contribution of intravenous (IV) fluid administration and rostral fluid shift from the legs to the neck thereby leading to worsening of sleep apnea follow...
Detailed Description
The study investigators hypothesize that in obstructive sleep apnea (OSA) patients undergoing elective non-cardiac surgery, preferential increase in neck fluid volume following intravenous administrat...
Eligibility Criteria
Inclusion
- Adult patients (\>18 yrs)
- Previously diagnosed OSA (AHI \> 10), untreated or non-compliant to treatment, or patients screened as suspected OSA (STOP Bang \>3, and confirmed to have OSA with AHI \> 10 on a portable sleep study)
- ASA physical status I - IV
- Patients undergoing elective non-cardiac surgery under general anesthesia;
- Patients requiring overnight admission.
Exclusion
- Patients compliant on OSA treatment such as continuous positive airway pressure therapy or an oral appliance
- Vascular surgery on the lower limbs, or metal implants in lower limbs
- Pregnant or lactating patients
- Cardiac, intra-cranial, or neck procedures.
- Inability to communicate: with health care providers or the research personnel, inability to perform breathing maneuvers such as spirometry, or inability to follow instructions.
Key Trial Info
Start Date :
July 22 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 14 2020
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03850041
Start Date
July 22 2019
End Date
December 14 2020
Last Update
June 23 2022
Active Locations (2)
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1
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
2
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8