Status:
TERMINATED
Impact of Early Enteral vs. Parenteral Nutrition on Preservation of Gut Mucosa Integrity in Patients Requiring Mechanical Ventilation and Catecholamine
Lead Sponsor:
Centre Hospitalier Departemental Vendee
Collaborating Sponsors:
Ministry of Health, France
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Acute Respiratory Failure
Shock
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To demonstrate that a strategy involving early first-line enteral nutrition is associated with improved preservation of gut mucosa integrity, as assessed based on the plasma citrulline level at H72, c...
Detailed Description
Published data suggest that enteral nutrition may be associated with improved preservation of the gut lymphoid tissues and gut immune function, as well as with decreased gut mucosa permeability, there...
Eligibility Criteria
Inclusion
- Invasive mechanical ventilation expected to be required more than 48 hours
- Nutrition started within 24 hours after initiation of endotracheal mechanical ventilation
- Treatment with vasoactive drug administered via a central venous catheter
- Age over 18 years
- Signed information
Exclusion
- Abdominal surgery within 1 month before inclusion
- History of esophageal, gastric, duodenal or pancreatic surgery
- Bleeding from the esophagus, stomach or bowel
- enteral nutrition via gastrostomy or jejunostomy
- pregnancy
- Treatment-limitation decisions
- Current inclusion in a trial on comparison between enteral and parenteral nutrition
Key Trial Info
Start Date :
January 27 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2017
Estimated Enrollment :
169 Patients enrolled
Trial Details
Trial ID
NCT03852940
Start Date
January 27 2015
End Date
July 1 2017
Last Update
February 25 2019
Active Locations (6)
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1
CHU Amiens
Amiens, France, 80054
2
Centre hospitalier d'Annecy
Annecy, France, 74374
3
CH de Dieppe
Dieppe, France, 76202
4
CHU Lille
Lille, France, 59000