Status:
COMPLETED
Air Pollution and Children With Cystic Fibrosis
Lead Sponsor:
Queen Mary University of London
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
1-17 years
Brief Summary
1. To determine personal exposure to air pollution in children with cystic fibrosis; 2. To determine airway macrophage uptake of inhaled particulate matter in cystic fibrosis children; 3. To establish...
Detailed Description
Background: Cystic fibrosis (CF) is the commonest hereditary life-shortening respiratory condition, resulting in premature death secondary to recurrent airway infections and inflammation, leading to ...
Eligibility Criteria
Inclusion
- Age 1-17
- Diagnosis of Cystic Fibrosis
- Diagnosis of non-CF bronchiectasis
- Living in or around London With age matched healthy controls
Exclusion
- Current active smoker
- Receiving immunosuppressive drug therapy
- For children with CF not on regular nebulised hypertonic saline: drop in FEV1 of \>15% post-bronchodilator (exclusion criterion for sputum induction)
- For healthy controls: Post-bronchodilator FEV1 \<80% (standard exclusion criterion for sputum induction in healthy individuals)
- For participants currently or recently involved in other research study, they will be excluded if their current or recent research have any potential impact on our sampling or results.
Key Trial Info
Start Date :
February 15 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 30 2020
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03853629
Start Date
February 15 2017
End Date
January 30 2020
Last Update
March 10 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Queen Mary University of London
London, United Kingdom, E1 2AT