Status:
COMPLETED
Aging Brain Structure and Memory in Response to Exercise
Lead Sponsor:
University of Delaware
Collaborating Sponsors:
Christiana Care Health Services
University of Illinois at Urbana-Champaign
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
60-90 years
Phase:
NA
Brief Summary
This study will measure brain structure through its mechanical properties, assessed with magnetic resonance elastography, and determine whether it improves with aerobic exercise in older adults with l...
Detailed Description
Mechanical properties of the human brain, measured with magnetic resonance elastography (MRE), reflect the health of brain tissue. Our previous research has shown that these mechanical properties of t...
Eligibility Criteria
Inclusion
- Cognitive function scores consistent with amnestic mild cognitive impairment based on pre-screening evaluation
- age 60-90 years
- MMSE score \>24 at time of initial consent
Exclusion
- major psychiatric disorder (e.g. schizophrenia, bipolar disorder, major depression within past two years)
- neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, head trauma with loss of consciousness greater than 30 min, large vessel infarct)
- other systemic medical illnesses (e.g. cardiovascular disease, cancer, renal failure, diabetes, chronic obstructive pulmonary disease, liver diseases, hypertension)
- current medication use likely to affect CNS functions (e.g. long active benzodiazepines)
- failed outcome on the baseline graded exercise test
- hypertension (systolic 130+ mmHg OR diastolic 80+ mmHg) from baseline blood pressure measurement
- claustrophobia, metal implants, pacemaker or other factors affecting feasibility and/or safety of MRI scanning
- concussion within last 2 years and more than 3 lifetime concussions
- current smoking (including marijuana) within the past 3 months
Key Trial Info
Start Date :
March 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2024
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT03855475
Start Date
March 1 2019
End Date
March 31 2024
Last Update
May 14 2024
Active Locations (1)
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1
University of Delaware
Newark, Delaware, United States, 19713