Status:
COMPLETED
This Study Tests Whether BI 425809 Together With Brain Training Using a Computer Improves Mental Functioning in Patients With Schizophrenia
Lead Sponsor:
Boehringer Ingelheim
Conditions:
Schizophrenia
Eligibility:
All Genders
18-50 years
Phase:
PHASE2
Brief Summary
This is a study in adults with schizophrenia. The study tests whether a medicine called BI 425809 together with brain training improves mental abilities. Participants take study medication once a day...
Eligibility Criteria
Inclusion
- Signed and dated written informed consent in accordance with ICH Harmonized Tripartite Guideline for Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial.
- Male or female patients who are 18-50 years (inclusive) of age at time of consent.
- Established schizophrenia (as per DSM-5) with the following clinical features:
- Outpatient, with no hospitalization for worsening of schizophrenia within 3 months prior to randomization
- Psychiatrically stable without symptom exacerbation within 3 months prior to randomization
- PANSS score ≤ 5 on positive items P1, P3-P7 and ≤ 4 on positive item P2 at Visit 1, and confirmed at Visit 2
- Patients must be on stable antipsychotic treatment; also, current antipsychotic medications and concomitant anticholinergics, antiepileptics, lithium and allowed antidepressants must meet the criteria below:
- Patients must take 1 and may take up to 2 antipsychotics (typical and/or atypical), except for clozapine
- Patients must be stable on current antipsychotics, anticholinergics, antiepileptics, lithium and allowed antidepressants for at least 3 months prior to randomization and be on current dose for at least 30 days prior to randomization o Patients on Long-Acting Injectable (LAI) antipsychotics should be on the same medication and dose for at least 3 months prior to randomization
- Women of childbearing potential (WOCBP)2 must be ready and able to use highly effective methods of birth control per Non-Clinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals (ICH M3 (R2)) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in Section 4.2.2.3. Such methods should be used throughout the trial, and for a period of at least 35 days after last trial drug intake, and the patient must agree to periodic pregnancy testing during participation in the trial.
- Patients must demonstrate their ability to properly use the CCT device and program, as well as be compliant with CCT run-in (defined as completing at least 2 hours per week for two weeks, totalling 4 hours CCT, during the screening period)3.
- Patients must be able to comply with all protocol procedures, in the investigator's opinion.
- Patients must have a study partner who will preferably be consistent throughout the study. It is recommended that the study partner should interact (in-person or telephone) with the subject at least 2 times a week.
Exclusion
- Patients who have a categorical diagnosis of another current major psychiatric disorder on the Mini-International Neuropsychiatric Interview (M.I.N.I.).
- Diseases of the central nervous system (CNS) that may impact the assessment of the cognitive tests as per investigator's opinion. A movement disorder due to antipsychotic treatment not currently controlled with anti- EPS treatment or another movement disorder (e.g. Parkinson´s disease).
- Patients with a history of participating in any formal cognitive remediation program for 10 or more training sessions.
- Patients who were treated with any of the following medications within the last 6 months prior to randomization:
- Bitopertin, BI 409306, encenicline or other investigational drug testing effects on cognition in schizophrenia
- Clozapine (atypical antipsychotic medication)
- Sarcosine, cycloserine, serine and glycine
- Stimulants (e.g. methylphenidate, dextroamphetamine, modafinil)
- Tricyclic antidepressants
- Patients receiving any other investigational drug (other than a potential cognitive enhancing drug) within 30 days or 6 half-lives (whichever is longer) prior to randomization. For investigational LAI antipsychotics, the last injection must be at least 3 months or two administration cycles (i.e. 6 months if administration is every 3 months) prior to randomization, whichever is longer.
- Patients who have participated in a clinical trial with repeated assessments (i.e. a single assessment is not exclusionary) with the MATRICS Consensus Cognitive Battery (MCCB) within the last 6 months prior to randomization.
- Patients who required a change in ongoing benzodiazepine or sleep medication dose or regimen within the last 30 days prior to randomization.
- Patients with known active infection with SARS-CoV-2 within the last 30 days prior to randomization.
- Other exclusion criteria apply
Key Trial Info
Start Date :
April 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 4 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03859973
Start Date
April 15 2019
End Date
November 4 2022
Last Update
November 18 2023
Active Locations (50)
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1
Atria Clinical Research
Little Rock, Arkansas, United States, 72209
2
Woodland Research Northwest
Rogers, Arkansas, United States, 72758
3
Encino Hospital Medical Center
Encino, California, United States, 91436
4
Collaborative Neuroscience Network, LLC (CNS)
Garden Grove, California, United States, 92845