Status:
COMPLETED
Effect of Oral Feeding on Gastric Emptying, Gut Blood Flow, and Hormone Responses in Obese and Healthy Weight Subjects
Lead Sponsor:
University of Nottingham
Conditions:
Obesity
Eligibility:
MALE
18-60 years
Brief Summary
Obesity is a complicated condition that is poorly understood. The aim of this study is to increase our knowledge of how the condition may arise, and what makes obese people remain obese. We will be i...
Detailed Description
The World Health Organisation (WHO) has deemed being overweight or obese as the fifth leading cause for global deaths, with more than 1.9 billion adults being defined as overweight, and 600 million de...
Eligibility Criteria
Inclusion
- BMI 30-40 kg/m2
- BMI 18-25 kg/m2; those with BMI up to 28kg/m2 will be included if waist circumference is \<96cm.
- Males
- Aged 18-60yrs
Exclusion
- Acute illness in the preceding 6 weeks
- Taking regular medication
- History of deep vein thrombosis or clotting disorders
- Hypertension
- Diabetes
- Any clinically significant findings at screening
- History of substance abuse
- Demonstrating factors precluding safe MRI
- History of gastrointestinal motility disorders (e.g. gastroesophageal reflux disease -irritable bowel syndrome, gastroparesis, sphincter of Oddi dysfunction, etc.)
- Previous thoracic or abdominal surgery.
- Those who report having ≤3 bowel movements/week or \>2/day.
Key Trial Info
Start Date :
November 7 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 28 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03860623
Start Date
November 7 2018
End Date
October 28 2022
Last Update
December 4 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Queens Medical Centre
Nottingham, Notts, United Kingdom, NG72UH